Translational Nephrology

Module Overview


Module 1:  Salt, Water and Hypertension

  • Basics on renal Na+, K+, Cl- and water handling and their hormonal regulation
  • Impact of dietary Na+ and K+ intake on blood pressure and the aldosterone paradox
  • Cellular and molecular mechanism of arterial hypertension and disturbed water balance

Module 2:  Acid-base Homeostasis

  • Tubular mechanism of renal handling of acids and bases
  • Control of acid-base homeostasis and the respective role of the kidney, the lung and other organs
  • Mechanism of renal tubular acidosis and other kidney-related disturbances in acid-base balance

Module 3: Calcium and Phosphate

  • Physiology and pathophysiology of renal tubular handling of divalent cations and the involved hormonal control systems
  • Pathogenesis of vascular and urinary calcifications

Module 4: Oxygen Signaling and Cancer

  • General mechanism of cellular oxygen sensing
  • Physiology and pathophysiology of renal erythropoietin production
  • VHL disease and clear cell renal cell carcinoma

Module 5: Metabolism and Kidney Function

  • Dietary proteins and kidney function: amino acid transport, kidney growth, nitrogen disposal and water handling
  • GFR as measure of kidney function, role of age and relation to kidney volume

Module 6: Inflammation and Immunology

  • Inflammation and progression of chronic kidney disease
  • Direct and indirect immune-mediated renal diseases
  • Immune system in kidney transplantation