Translational Nephrology

Module Overview

Module 1:  Salt and Water Transport

  • Basics in anatomy and physiology of renal sodium handling and its regulation by the renin-angiotensin-aldosterone system
  • Concepts of blood pressure control and the importance of the kidney
  • Cellular and molecular mechanism of hypertension

Module 2:  Acid-base homeostasis

  • Tubular mechanism of renal handling of acids and bases
  • Control of acid-base homeostasis and the respective role of the kidney, the lung and other organs
  • Mechanism of renal tubular acidosis and other kidney-related disturbances in acid-base balance

Module 3: Calcium and phosphate homeostasis

  • Physiology and pathophysiology of renal tubular handling of divalent cations and the involved hormonal control systems
  • Pathogenesis of vascular and urinary calcifications

Module 4:  Oxygen Sensing

  • General mechanism of cellular oxygen sensing.
  • Physiology and pathophysiology of renal erythropoietin production
  • VHL disease and clear cell renal cell carcinoma

Module 5: Nutrient & Metabolism

  • Renal and extrarenal potassium handling and its dietary impact on blood pressure
  • Dietary proteins and kidney function: amino acid transport, kidney growth and nitrogen disposal
  • GFR as measure of kidney function, role of age and relation to kidney volume